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Intern-S1-Pro: Scientific Multimodal Foundation Model at Trillion Scale

Paper · 2026 · Yicheng Zou, Dongsheng Zhu, Lin Zhu et al.

Summary

Intern-S1-Pro, from Shanghai AI Laboratory, is presented as the first scientific multimodal foundation model with one trillion parameters. The authors argue that science spans many fields, each with its own notation and reasoning style, so one model needs very large capacity to cover them all. They built it by expanding the experts of the earlier Intern-S1 Mixture-of-Experts model. Two changes to the router address training problems at this scale. Grouped Routing keeps the load evenly spread across devices. A Straight-Through Estimator lets every router embedding receive gradient updates.

The model was further pre-trained on 6T multimodal tokens. This included captions for scientific figures produced by a dedicated pipeline. It was then refined with agentic reinforcement learning on XTuner and LMDeploy, which kept training and inference numerically consistent. The model handles more than 100 scientific tasks and ranks among the top open-source models on general benchmarks. A biology case study suggests that a large generalist trained jointly can beat a domain specialist trained on the same data. The weights are released on Hugging Face (internlm/Intern-S1-Pro).

Key points

  • Grouped Routing: with k=8 and EP8, the experts are split into 8 device-aligned groups and one expert is chosen per group. This gives exact load balance across devices and removes the out-of-memory risk caused by imbalance.
  • Expert initialization: each group of the expanded model is seeded with the pre-expansion Top-1/Top-2 experts. In a 30BA3 test, spreading Top-1 to Top-8 experts across groups instead cost more than 20 points.
  • Efficiency: the model is about 4× the size of Intern-S1, yet training efficiency dropped by only about 20%.
  • Vision encoder: a native-resolution ViT trained contrastively on roughly 300M image–text pairs from CC12M, LAION-COCO, SBU Caption, LAION-2B-Multi and Wukong. The model also uses FoPE positional encoding.
  • Biology case study: against Biology-Instruction, the average score rose from 39.24 to 52.45. Protein-Fluorescence went from 2.57 to 78.14 and Protein-FunctionEC from 19.79 to 72.70.

Our summary of the paper, in our own words — not its text. The work belongs to its authors; read it at the links above.

 Fields, topics and concepts

📚 Shelves 5The field of science this work belongs to (OpenAlex fields).Computer Science · 16,667 worksArtificial Intelligence · 16,194 worksArts and Humanities · 16,039 worksLanguage and Linguistics · 15,891 worksComputer Vision and Pattern Recognition · 2,869 works

🧭 Topics 2Research subjects and languages the work is about.Language models & pretraining · 3,320 worksVision & language · 657 works

Cite

Cite as Yicheng Zou, Dongsheng Zhu, Lin Zhu, Tong Zhu, Yunhua Zhou, Peiheng Zhou, Xinyu Zhou, Dongzhan Zhou, Zhiwang Zhou, Yuhao Zhou, Bowen Zhou, Zhanping Zhong, Zhijie Zhong, Haiteng Zhao, Penghao Zhao, Xiaomeng Zhao, Zhiyuan Zhao, Yechen Zhang, Jin Zhang, Wenwei Zhang, Hongjie Zhang, Zhuo Zhang, Wenlong Zhang, Bo Zhang, Chao Zhang, Chen Zhang, Yuhang Zang, Fei Yuan, Jiakang Yuan, Jiashuo Yu, Jinhui Yin, Haochen Ye, Qian Yao, Bowen Yang, Danni Yang, Kaichen Yang, Ziang Yan, Jun Xu, Yicheng Xu, Wanghan Xu, Xuenan Xu, Chao Xu, Ruiliang Xu, Shuhao Xing, Long Xing, Xinchen Xie, Ling-I Wu, Zijian Wu, Zhenyu Wu, Lijun Wu, Yue Wu, Jianyu Wu, Wen Wu, Fan Wu, Xilin Wei, Qi Wei, Bingli Wang, Rui Wang, Ziyi Wang, Zun Wang, Yi Wang, Haomin Wang, Yizhou Wang, Lintao Wang, Yiheng Wang, Longjiang Wang, Bin Wang, Jian Tong, Zhongbo Tian, Huanze Tang, Chen Tang, Shixiang Tang, Yu Sun, Qiushi Sun, Xuerui Su, Qisheng Su, Chenlin Su, Demin Song, Jin Shi, Fukai Shang, Yuchen Ren, Pengli Ren, Xiaoye Qu, Yuan Qu, Jiantao Qiu, Yu Qiao, Biqing Qi, Runyu Peng, Tianshuo Peng, Jiahui Peng, Qizhi Pei, Zhuoshi Pan, Linke Ouyang, Wenchang Ning, Yichuan Ma, Zerun Ma, Ningsheng Ma, Runyuan Ma, Chengqi Lyu, Haijun Lv, Han Lv, Lindong Lu, Kuikun Liu, Jiangning Liu, Yuhong Liu, Kai Liu, Hongwei Liu, Zhoumianze Liu, Mengjie Liu, Ziyu Liu, Wenran Liu, Yang Liu, Liwei Liu, Kaiwen Liu, Junyao Lin, Junming Lin, Tianyang Lin, Dahua Lin, Jianze Liang, Linyang Li, Peiji Li, Zonglin Li, Zehao Li, Pengze Li, Guoyan Li, Lingkai Kong, Linglin Jing, Zhenjiang Jin, Feifei Jiang, Qian Jiang, Junhao Huang, Zixian Huang, Haian Huang, Zhouqi Hua, Ermo Hua, Han Hu, Linfeng Hou, Yinan He, Conghui He, Tianyao He, Xu Guo, Qipeng Guo, Aijia Guo, Yuzhe Gu, Lixin Gu, Jingyang Gong, Qiming Ge, Jiaye Ge, Songyang Gao, Jianfei Gao, Xinyu Fang, Caihua fan, Yue Fan, Yanhui Duan, Zichen Ding, Shengyuan Ding, Ning Ding, Xuanlang Dai, Erfei Cui, Ganqu Cui, Pei Chu, Tao Chu, Guangran Cheng, Yu Cheng, Kai Chen, Yongkang Chen, Chiyu Chen, Guanzhou Chen, Qiaosheng Chen, Sitao Chen, Xin Chen, Haojiong Chen, Yicheng Chen, Weihan Cao, Yuhang Cao, Qinglong Cao and Lei Bai. 2026. Intern-S1-Pro: Scientific Multimodal Foundation Model at Trillion Scale. arXiv:2603.25040.

The paper itself, not this page. BibTeX from the library's record of the work. DOI 10.48550/arxiv.2603.25040 · arXiv 2603.25040

@misc{zou2026intern,
  title = {{Intern-S1-Pro: Scientific Multimodal Foundation Model at Trillion Scale}},
  author = {Yicheng Zou, Dongsheng Zhu, Lin Zhu, Tong Zhu, Yunhua Zhou, Peiheng Zhou, Xinyu Zhou, Dongzhan Zhou, Zhiwang Zhou, Yuhao Zhou, Bowen Zhou, Zhanping Zhong, Zhijie Zhong, Haiteng Zhao, Penghao Zhao, Xiaomeng Zhao, Zhiyuan Zhao, Yechen Zhang, Jin Zhang, Wenwei Zhang, Hongjie Zhang, Zhuo Zhang, Wenlong Zhang, Bo Zhang, Chao Zhang, Chen Zhang, Yuhang Zang, Fei Yuan, Jiakang Yuan, Jiashuo Yu, Jinhui Yin, Haochen Ye, Qian Yao, Bowen Yang, Danni Yang, Kaichen Yang, Ziang Yan, Jun Xu, Yicheng Xu, Wanghan Xu, Xuenan Xu, Chao Xu, Ruiliang Xu, Shuhao Xing, Long Xing, Xinchen Xie, Ling-I Wu, Zijian Wu, Zhenyu Wu, Lijun Wu, Yue Wu, Jianyu Wu, Wen Wu, Fan Wu, Xilin Wei, Qi Wei, Bingli Wang, Rui Wang, Ziyi Wang, Zun Wang, Yi Wang, Haomin Wang, Yizhou Wang, Lintao Wang, Yiheng Wang, Longjiang Wang, Bin Wang, Jian Tong, Zhongbo Tian, Huanze Tang, Chen Tang, Shixiang Tang, Yu Sun, Qiushi Sun, Xuerui Su, Qisheng Su, Chenlin Su, Demin Song, Jin Shi, Fukai Shang, Yuchen Ren, Pengli Ren, Xiaoye Qu, Yuan Qu, Jiantao Qiu, Yu Qiao, Biqing Qi, Runyu Peng, Tianshuo Peng, Jiahui Peng, Qizhi Pei, Zhuoshi Pan, Linke Ouyang, Wenchang Ning, Yichuan Ma, Zerun Ma, Ningsheng Ma, Runyuan Ma, Chengqi Lyu, Haijun Lv, Han Lv, Lindong Lu, Kuikun Liu, Jiangning Liu, Yuhong Liu, Kai Liu, Hongwei Liu, Zhoumianze Liu, Mengjie Liu, Ziyu Liu, Wenran Liu, Yang Liu, Liwei Liu, Kaiwen Liu, Junyao Lin, Junming Lin, Tianyang Lin, Dahua Lin, Jianze Liang, Linyang Li, Peiji Li, Zonglin Li, Zehao Li, Pengze Li, Guoyan Li, Lingkai Kong, Linglin Jing, Zhenjiang Jin, Feifei Jiang, Qian Jiang, Junhao Huang, Zixian Huang, Haian Huang, Zhouqi Hua, Ermo Hua, Han Hu, Linfeng Hou, Yinan He, Conghui He, Tianyao He, Xu Guo, Qipeng Guo, Aijia Guo, Yuzhe Gu, Lixin Gu, Jingyang Gong, Qiming Ge, Jiaye Ge, Songyang Gao, Jianfei Gao, Xinyu Fang, Caihua fan, Yue Fan, Yanhui Duan, Zichen Ding, Shengyuan Ding, Ning Ding, Xuanlang Dai, Erfei Cui, Ganqu Cui, Pei Chu, Tao Chu, Guangran Cheng, Yu Cheng, Kai Chen, Yongkang Chen, Chiyu Chen, Guanzhou Chen, Qiaosheng Chen, Sitao Chen, Xin Chen, Haojiong Chen, Yicheng Chen, Weihan Cao, Yuhang Cao, Qinglong Cao and Lei Bai},
  year = {2026},
  doi = {10.48550/arxiv.2603.25040},
  eprint = {2603.25040},
  archivePrefix = {arXiv},
  url = {https://doi.org/10.48550/arxiv.2603.25040}
}

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