Elamur Research⌕
☰
home / papers / 2024 / Capabilities of Gemini Models in Medicine

Capabilities of Gemini Models in Medicine

Paper · 2024 · Khaled Saab, Tao Tu, Wei-Hung Weng et al.

Summary

Medical AI must reason carefully, use current knowledge, and interpret images, video and long patient records. This Google Research / Google DeepMind paper presents Med-Gemini, a family of medicine-specialized models built on Gemini 1.0 and Gemini 1.5. For text reasoning, the authors self-train the models to use web search. At inference time, the model runs searches when it appears unsure of its answer, which the authors call an uncertainty-guided strategy. For unfamiliar data types, they apply multimodal fine-tuning and custom encoders. Long inputs are handled through in-context learning alone. Across 14 benchmarks covering text, multimodal and long-context tasks, Med-Gemini sets a new state of the art on 10. It also beats GPT-4-family models wherever a fair comparison exists. Clinicians relabelled MedQA (USMLE) and found a share of flawed items. Med-Gemini outperformed human experts on note summarization and referral letter writing. The work shows that a general multimodal LLM can be adapted to many clinical tasks. The authors stress that rigorous safety testing must come before deployment, and model weights are not released.

Key points

  • MedQA (USMLE): 91.1% accuracy, 4.6 points above Med-PaLM 2 (86.5%) and above GPT-4 (90.2%). The search strategy also achieved top results on NEJM clinico-pathological conference cases and GeneTuring.
  • Expert re-annotation judged 7.4% of MedQA questions unsuitable because of missing information, wrong keys or ambiguity. The relabelled set is to be made public.
  • On 7 multimodal benchmarks, including the NEJM Image Challenge and MMMU (health & medicine), Med-Gemini beats GPT-4V by 44.5% on average in relative terms.
  • Long-context results include state-of-the-art needle-in-a-haystack retrieval from de-identified health records and medical video QA, using only in-context learning.
  • Code and weights are withheld for safety reasons, with access expected later via Google Cloud APIs. All authors are Alphabet employees.

Our summary of the paper, in our own words — not its text. The work belongs to its authors; read it at the links above.

 Fields, topics and concepts

Cite

Cite as Khaled Saab, Tao Tu, Wei-Hung Weng, Ryutaro Tanno, David Stutz, Ellery Wulczyn, Fan Zhang, Tim Strother, Chunjong Park, Elahe Vedadi, Juanma Zambrano Chaves, Szu-Yeu Hu, Mike Schaekermann, Aishwarya Kamath, Yong Cheng, David G.T. Barrett, Cathy Cheung, Basil Mustafa, Anil Palepu, Daniel McDuff, Le Hou, Tomer Golany, Luyang Liu, Jean-baptiste Alayrac, Neil Houlsby, Nenad Tomasev, Jan Freyberg, Charles Lau, Jonas Kemp, Jeremy Lai, Shekoofeh Azizi, Kimberly Kanada, SiWai Man, Kavita Kulkarni, Ruoxi Sun, Siamak Shakeri, Luheng He, Ben Caine, Albert Webson, Natasha Latysheva, Melvin Johnson, Philip Mansfield, Jian Lu, Ehud Rivlin, Jesper Anderson, Bradley Green, Renee Wong, Jonathan Krause, Jonathon Shlens, Ewa Dominowska, S. M. Ali Eslami, Katherine Chou, Claire Cui, Oriol Vinyals, Koray Kavukcuoglu, James Manyika, Jeff Dean, Demis Hassabis, Yossi Matias, Dale Webster, Joelle Barral, Greg Corrado, Christopher Semturs, S. Sara Mahdavi, Juraj Gottweis, Alan Karthikesalingam and Vivek Natarajan. 2024. Capabilities of Gemini Models in Medicine. arXiv:2404.18416.

The paper itself, not this page. BibTeX from the library's record of the work. DOI 10.48550/arxiv.2404.18416 · arXiv 2404.18416

@misc{saab2024capabilities,
  title = {{Capabilities of Gemini Models in Medicine}},
  author = {Khaled Saab, Tao Tu, Wei-Hung Weng, Ryutaro Tanno, David Stutz, Ellery Wulczyn, Fan Zhang, Tim Strother, Chunjong Park, Elahe Vedadi, Juanma Zambrano Chaves, Szu-Yeu Hu, Mike Schaekermann, Aishwarya Kamath, Yong Cheng, David G.T. Barrett, Cathy Cheung, Basil Mustafa, Anil Palepu, Daniel McDuff, Le Hou, Tomer Golany, Luyang Liu, Jean-baptiste Alayrac, Neil Houlsby, Nenad Tomasev, Jan Freyberg, Charles Lau, Jonas Kemp, Jeremy Lai, Shekoofeh Azizi, Kimberly Kanada, SiWai Man, Kavita Kulkarni, Ruoxi Sun, Siamak Shakeri, Luheng He, Ben Caine, Albert Webson, Natasha Latysheva, Melvin Johnson, Philip Mansfield, Jian Lu, Ehud Rivlin, Jesper Anderson, Bradley Green, Renee Wong, Jonathan Krause, Jonathon Shlens, Ewa Dominowska, S. M. Ali Eslami, Katherine Chou, Claire Cui, Oriol Vinyals, Koray Kavukcuoglu, James Manyika, Jeff Dean, Demis Hassabis, Yossi Matias, Dale Webster, Joelle Barral, Greg Corrado, Christopher Semturs, S. Sara Mahdavi, Juraj Gottweis, Alan Karthikesalingam and Vivek Natarajan},
  year = {2024},
  doi = {10.48550/arxiv.2404.18416},
  eprint = {2404.18416},
  archivePrefix = {arXiv},
  url = {https://doi.org/10.48550/arxiv.2404.18416}
}

References

148 references, 39 of them with a card of ours. ↗ leads to the work, «find» searches for one we have no id for yet.

  1. M. D. Abràmoff, M. E. Tarver, N. Loyo-Berrios, S. Trujillo, D. Char, Z. Obermeyer, M. B. Eydelman, F. P. of Ophthalmic Imaging, D. Algorithmic Interpretation Working Group of the Collaborative Community for Ophthalmic Imaging Foundation, Washington, and W. H. Maisel. Considerations for addressing bi… find
  2. J. Achiam, S. Adler, S. Agarwal, L. Ahmad, I. Akkaya, F. L. Aleman, D. Almeida, J. Altenschmidt, S. Altman, S. Anadkat, et al. GPT-4 technical report. arXiv preprint arXiv:2303.08774, 2023.
  3. J.-B. Alayrac, J. Donahue, P. Luc, A. Miech, I. Barr, Y. Hasson, K. Lenc, A. Mensch, K. Millican, M. Reynolds, et al. Flamingo: a visual language model for few-shot learning. Advances in neural information processing systems, 35:23716–23736, 2022.
  4. R. Anil, A. M. Dai, O. Firat, M. Johnson, D. Lepikhin, A. Passos, S. Shakeri, E. Taropa, P. Bailey, Z. Chen, et al. PaLM 2 technical report. arXiv preprint arXiv:2305.10403, 2023.
  5. F. Antaki, D. Milad, M. A. Chia, C.-É. Giguère, S. Touma, J. El-Khoury, P. A. Keane, and R. Duval. Capabilities of GPT-4 in ophthalmology: an analysis of model entropy and progress towards human-level medical question answering. British Journal of Ophthalmology, 2023. find
  6. S. Azizi, L. Culp, J. Freyberg, B. Mustafa, S. Baur, S. Kornblith, T. Chen, N. Tomasev, J. Mitrović, P. Strachan, et al. Robust and data-efficient generalization of self-supervised machine learning for diagnostic imaging. Nature Biomedical Engineering, 7(6):756–779, 2023. find
  7. P. Barham, A. Chowdhery, J. Dean, S. Ghemawat, S. Hand, D. Hurt, M. Isard, H. Lim, R. Pang, S. Roy, et al. Pathways: Asynchronous distributed dataflow for ML. Proceedings of Machine Learning and Systems, 4:430–449, 2022. find
  8. M. Besta, N. Blach, A. Kubicek, R. Gerstenberger, M. Podstawski, L. Gianinazzi, J. Gajda, T. Lehmann, H. Niewiadomski, P. Nyczyk, and T. Hoefler. Graph of thoughts: Solving elaborate problems with large language models, 2024. find
  9. T. Brown, B. Mann, N. Ryder, M. Subbiah, J. D. Kaplan, P. Dhariwal, A. Neelakantan, P. Shyam, G. Sastry, A. Askell, et al. Language models are few-shot learners. Advances in neural information processing systems, 33:1877–1901, 2020.
  10. T. Buckley, J. A. Diao, A. Rodman, and A. K. Manrai. Accuracy of a vision-language model on challenging medical cases. arXiv preprint arXiv:2311.05591, 2023. — [arXiv:2311.05591](https://arxiv.org/abs/2311.05591) find
  11. Á. A. Cabrera, W. Epperson, F. Hohman, M. Kahng, J. Morgenstern, and D. H. Chau. Fairvis: Visual analytics for discovering intersectional bias in machine learning. In 2019 IEEE Conference on Visual Analytics Science and Technology (VAST), pages 46–56. find
  12. T. Cai, X. Wang, T. Ma, X. Chen, and D. Zhou. Large language models as tool makers. arXiv preprint arXiv:2305.17126, 2023.
  13. D. S. Char, N. H. Shah, and D. Magnus. Implementing machine learning in health care—addressing ethical challenges. The New England journal of medicine, 378(11):981, 2018. find
  14. W. Chen, J. Feng, J. Lu, and J. Zhou. Endo3d: Online workflow analysis for endoscopic surgeries based on 3d cnn and lstm. In OR 2.0 Context-Aware Operating Theaters, Computer Assisted Robotic Endoscopy, Clinical Image-Based Procedures, and Skin Image Analysis: First International Workshop, OR 2.0 20… find
  15. X. Chen, X. Wang, S. Changpinyo, A. Piergiovanni, P. Padlewski, D. Salz, S. Goodman, A. Grycner, B. Mustafa, L. Beyer, et al. PaLI: A jointly-scaled multilingual language-image model. arXiv preprint arXiv:2209.06794, 2022.
  16. A. Chowdhery, S. Narang, J. Devlin, M. Bosma, G. Mishra, A. Roberts, P. Barham, H. W. Chung, C. Sutton, S. Gehrmann, et al. PaLM: Scaling language modeling with pathways. Journal of Machine Learning Research, 24(240):1–113, 2023.
  17. D. Cirillo, S. Catuara-Solarz, C. Morey, E. Guney, L. Subirats, S. Mellino, A. Gigante, A. Valencia, M. J. Rementeria, A. S. Chadha, et al. Sex and gender differences and biases in artificial intelligence for biomedicine and healthcare. NPJ digital medicine, 3(1):1–11, 2020. find
  18. M. Claussnitzer, S. N. Dankel, K.-H. Kim, G. Quon, W. Meuleman, C. Haugen, V. Glunk, I. S. Sousa, J. L. Beaudry, V. Puviindran, et al. Fto obesity variant circuitry and adipocyte browning in humans. New England Journal of Medicine, 373(10):895–907, 2015. find
  19. Cochrane. Standards for reporting plain language summaries (pls) for cochrane diagnostic test accuracy reviews, 2014. https://methods.cochrane.org/sites/methods.cochrane.org.sdt/files/uploads/Draft PLS document.pdf. ↗
  20. E. D. Cubuk, B. Zoph, J. Shlens, and Q. V. Le. Randaugment: Practical automated data augmentation with a reduced search space. In Proceedings of the IEEE/CVF conference on computer vision and pattern recognition workshops, pages 702–703, 2020. find
  21. X. Dai, I. Chalkidis, S. Darkner, and D. Elliott. Revisiting transformer-based models for long document classification. arXiv preprint arXiv:2204.06683, 2022. find
  22. Z. Dai, Z. Yang, Y. Yang, J. Carbonell, Q. V. Le, and R. Salakhutdinov. Transformer-XL: Attentive language models beyond a fixed-length context. arXiv preprint arXiv:1901.02860, 2019. find
  23. P. Densen. Challenges and opportunities facing medical education. Transactions of the American Clinical and Climatological Association, 122:48, 2011. find
  24. A. Devaraj, I. Marshall, B. Wallace, and J. J. Li. Paragraph-level simplification of medical texts. In Proceedings of the 2021 Conference of the North American Chapter of the Association for Computational Linguistics, pages 4972–4984. Association for Computational Linguistics, June 2021. URL https:…
  25. J. Devlin, M.-W. Chang, K. Lee, and K. Toutanova. BERT: Pre-training of deep bidirectional transformers for language understanding. arXiv preprint arXiv:1810.04805, 2018.
  26. D. Driess, F. Xia, M. S. Sajjadi, C. Lynch, A. Chowdhery, B. Ichter, A. Wahid, J. Tompson, Q. Vuong, T. Yu, et al. PaLM-E: An embodied multimodal language model. arXiv preprint arXiv:2303.03378, 2023. find
  27. A. V. Eriksen, S. Möller, and J. Ryg. Use of GPT-4 to diagnose complex clinical cases, 2023. find
  28. A. Feder, I. Laish, S. Agarwal, U. Lerner, A. Atias, C. Cheung, P. Clardy, A. Peled-Cohen, R. Fellinger, H. Liu, et al. Building a clinically-focused problem list from medical notes. In Proceedings of the 13th International Workshop on Health Text Mining and Information Analysis (LOUHI), pages 60–68… find
  29. W. Fedus, B. Zoph, and N. Shazeer. Switch transformers: Scaling to trillion parameter models with simple and efficient sparsity. Journal of Machine Learning Research, 23(120):1–39, 2022. find
  30. S. L. Fleming, A. Lozano, W. J. Haberkorn, J. A. Jindal, E. P. Reis, R. Thapa, L. Blankemeier, J. Z. Genkins, E. Steinberg, A. Nayak, et al. Medalign: A clinician-generated dataset for instruction following with electronic medical records. arXiv preprint arXiv:2308.14089, 2023. find
  31. E. Ford, J. A. Carroll, H. E. Smith, D. Scott, and J. A. Cassell. Extracting information from the text of electronic medical records to improve case detection: a systematic review. Journal of the American Medical Informatics Association, 23(5):1007–1015, 2016. find
  32. I. R. Galatzer-Levy, D. McDuff, V. Natarajan, A. Karthikesalingam, and M. Malgaroli. The capability of large language models to measure psychiatric functioning. arXiv preprint arXiv:2308.01834, 2023. — [arXiv:2308.01834](https://arxiv.org/abs/2308.01834) find
  33. S. Ganapathi, J. Palmer, J. E. Alderman, M. Calvert, C. Espinoza, J. Gath, M. Ghassemi, K. Heller, F. Mckay, A. Karthikesalingam, et al. Tackling bias in ai health datasets through the standing together initiative. Nature Medicine, 28(11):2232–2233, 2022. find
  34. Y. Gao, Y. Xiong, X. Gao, K. Jia, J. Pan, Y. Bi, Y. Dai, J. Sun, Q. Guo, M. Wang, and H. Wang. Retrieval-augmented generation for large language models: A survey, 2024.
  35. Gemini Team, Google. Gemini: A family of highly capable multimodal models. arXiv preprint arXiv:2312.11805, 2023.
  36. Gemini Team, Google. Gemini 1.5: Unlocking multimodal understanding across millions of tokens of context. 2024. URL https://storage.googleapis.com/deepmind-media/gemini/ gemini_v1_5_report.pdf . ↗
  37. J. W. Gichoya, I. Banerjee, A. R. Bhimireddy, J. L. Burns, L. A. Celi, L.-C. Chen, R. Correa, N. Dullerud, M. Ghassemi, S.-C. Huang, et al. Ai recognition of patient race in medical imaging: a modelling study. The Lancet Digital Health, 4(6):e406–e414, 2022. find
  38. T. Golany, A. Aides, D. Freedman, N. Rabani, Y. Liu, E. Rivlin, G. S. Corrado, Y. Matias, W. Khoury, H. Kashtan, et al. Artificial intelligence for phase recognition in complex laparoscopic cholecystectomy. Surgical Endoscopy, 36(12):9215–9223, 2022. find
  39. E. D. Goodman, K. K. Patel, Y. Zhang, W. Locke, C. J. Kennedy, R. Mehrotra, S. Ren, M. Y. Guan, M. Downing, H. W. Chen, et al. A real-time spatiotemporal ai model analyzes skill in open surgical videos. arXiv preprint arXiv:2112.07219, 2021. — [arXiv:2112.07219](https://arxiv.org/abs/2112.07219) find
  40. E. D. Goodman, K. K. Patel, Y. Zhang, W. Locke, C. J. Kennedy, R. Mehrotra, S. Ren, M. Guan, O. Zohar, M. Downing, et al. Analyzing surgical technique in diverse open surgical videos with multitask machine learning. JAMA surgery, 159(2):185–192, 2024. find
  41. K. K. Grandage, D. C. Slawson, and A. F. Shaughnessy. When less is more: a practical approach to searching for evidence-based answers. Journal of the Medical Library Association, 90(3):298, 2002. find
  42. L. D. Gruppen. Clinical reasoning: defining it, teaching it, assessing it, studying it. Western Journal of Emergency Medicine, 18(1):4, 2017. find
  43. D. Gupta and D. Demner-Fushman. Overview of the MedVidQA 2022 shared task on medical video question-answering. In D. Demner-Fushman, K. B. Cohen, S. Ananiadou, and J. Tsujii, editors, Proceedings of the 21st Workshop on Biomedical Language Processing, pages 264–274, Dublin, Ireland, May 2022. Associ… find
  44. D. Gupta, K. Attal, and D. Demner-Fushman. A dataset for medical instructional video classification and question answering. Scientific Data, 10(1):158, 2023. find
  45. S. Hao, T. Liu, Z. Wang, and Z. Hu. ToolkenGPT: Augmenting frozen language models with massive tools via tool embeddings. Advances in neural information processing systems, 36, 2024.
  46. X. He, Z. Cai, W. Wei, Y. Zhang, L. Mou, E. Xing, and P. Xie. PathVQA: 30000+ questions for medical visual question answering. arXiv preprint arXiv:2010.12435, 2020. — [arXiv:2010.12435](https://arxiv.org/abs/2010.12435) find
  47. E. Horvitz, D. Heckerman, B. N. Nathwani, and L. M. Fagan. Diagnostic strategies in the hypothesis-directed pathfinder system. pages 630–636, January 1984. URL https://www.microsoft.com/en-us/research/publication/ diagnostic-strategies-hypothesis-directed-pathfinder-system/ . ↗
  48. W. Hou and Z. Ji. GeneTuring tests GPT models in genomics. BioRxiv, 2023. find
  49. J. Huang and K. C.-C. Chang. Towards reasoning in large language models: A survey, 2023.
  50. J. Huang, L. Neill, M. Wittbrodt, D. Melnick, M. Klug, M. Thompson, J. Bailitz, T. Loftus, S. Malik, A. Phull, et al. Generative artificial intelligence for chest radiograph interpretation in the emergency department. JAMA Network Open, 6(10):e2336100–e2336100, 2023. find
  51. S. L. Hyland, S. Bannur, K. Bouzid, D. C. Castro, M. Ranjit, A. Schwaighofer, F. Pérez-García, V. Salvatelli, S. Srivastav, A. Thieme, et al. MAIRA-1: A specialised large multimodal model for radiology report generation. arXiv preprint arXiv:2311.13668, 2023. — [arXiv:2311.13668](https://arxiv.org/abs/2311.13668) find
  52. J. Irvin, P. Rajpurkar, M. Ko, Y. Yu, S. Ciurea-Ilcus, C. Chute, H. Marklund, B. Haghgoo, R. Ball, K. Shpanskaya, et al. CheXpert: A large chest radiograph dataset with uncertainty labels and expert comparison. In Proceedings of the AAAI conference on artificial intelligence, volume 33, pages 590–59… find
  53. A. Iyer, G. Sen, and P. Östlin. The intersections of gender and class in health status and health care. Global public health, 3(S1):13–24, 2008. find
  54. S. E. Jackson, R. A. Hackett, and A. Steptoe. Associations between age discrimination and health and wellbeing: cross-sectional and prospective analysis of the english longitudinal study of ageing. The Lancet Public Health, 4(4):e200–e208, 2019. find
  55. P. B. Jensen, L. J. Jensen, and S. Brunak. Mining electronic health records: towards better research applications and clinical care. Nature Reviews Genetics, 13(6):395–405, 2012. find
  56. D. Jin, E. Pan, N. Oufattole, W.-H. Weng, H. Fang, and P. Szolovits. What disease does this patient have? a large-scale open domain question answering dataset from medical exams. Applied Sciences, 11(14):6421, 2021.
  57. Q. Jin, Y. Yang, Q. Chen, and Z. Lu. GeneGPT: Augmenting large language models with domain tools for improved access to biomedical information. Bioinformatics, 40(2):btae075, 2024.
  58. A. E. Johnson, T. J. Pollard, L. Shen, L.-w. H. Lehman, M. Feng, M. Ghassemi, B. Moody, P. Szolovits, L. Anthony Celi, and R. G. Mark. MIMIC-III, a freely accessible critical care database. Scientific data, 3(1):1–9, 2016.
  59. A. E. Johnson, T. J. Pollard, S. J. Berkowitz, N. R. Greenbaum, M. P. Lungren, C.-y. Deng, R. G. Mark, and S. Horng. MIMIC-CXR, a de-identified publicly available database of chest radiographs with free-text reports. Scientific data, 6(1):317, 2019a. find
  60. A. E. Johnson, T. J. Pollard, N. R. Greenbaum, M. P. Lungren, C.-y. Deng, Y. Peng, Z. Lu, R. G. Mark, S. J. Berkowitz, and S. Horng. MIMIC-CXR-JPG, a large publicly available database of labeled chest radiographs. arXiv preprint arXiv:1901.07042, 2019b. — [arXiv:1901.07042](https://arxiv.org/abs/1901.07042) find
  61. Z. Kanjee, B. Crowe, and A. Rodman. Accuracy of a generative artificial intelligence model in a complex diagnostic challenge. Jama, 330(1):78–80, 2023. find
  62. J. A. Kent, V. Patel, and N. A. Varela. Gender disparities in health care. Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine, 79(5):555–559, 2012. find
  63. I. Klerings, A. S. Weinhandl, and K. J. Thaler. Information overload in healthcare: too much of a good thing? Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen, 109(4-5):285–290, 2015. find
  64. R. Kouzy, J. Abi Jaoude, A. Kraitem, M. B. El Alam, B. Karam, E. Adib, J. Zarka, C. Traboulsi, E. W. Akl, and K. Baddour. Coronavirus goes viral: quantifying the covid-19 misinformation epidemic on twitter. Cureus, 12(3), 2020. find
  65. S. Laber, S. Forcisi, L. Bentley, J. Petzold, F. Moritz, K. S. Smirnov, L. Al Sadat, I. Williamson, S. Strobel, T. Agnew, et al. Linking the fto obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo. Science advances, 7(30):eabg0108, 2021. find
  66. T. Le Scao, A. Fan, C. Akiki, E. Pavlick, S. Ilić, D. Hesslow, R. Castagné, A. S. Luccioni, F. Yvon, M. Gallé, et al. Bloom: A 176b-parameter open-access multilingual language model. 2022. find
  67. G. Leifman, A. Aides, T. Golany, D. Freedman, and E. Rivlin. Pixel-accurate segmentation of surgical tools based on bounding box annotations. In 2022 26th International Conference on Pattern Recognition (ICPR), pages 5096–5103. find
  68. B. Li, Y. Weng, B. Sun, and S. Li. Towards visual-prompt temporal answering grounding in medical instructional video. arXiv preprint arXiv:2203.06667, 2022. — [arXiv:2203.06667](https://arxiv.org/abs/2203.06667) find
  69. C. Li, C. Wong, S. Zhang, N. Usuyama, H. Liu, J. Yang, T. Naumann, H. Poon, and J. Gao. LLaVa-Med: Training a large language-and-vision assistant for biomedicine in one day. Advances in Neural Information Processing Systems, 36, 2024.
  70. Y. Li, R. M. Wehbe, F. S. Ahmad, H. Wang, and Y. Luo. A comparative study of pretrained language models for long clinical text. Journal of the American Medical Informatics Association, 30(2):340–347, 2023. find
  71. B. Liu, L.-M. Zhan, L. Xu, L. Ma, Y. Yang, and X.-M. Wu. Slake: A semantically-labeled knowledge-enhanced dataset for medical visual question answering. In 2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI), pages 1650–1654. find
  72. M. Liu, Y. Ning, S. Teixayavong, M. Mertens, J. Xu, D. S. W. Ting, L. T.-E. Cheng, J. C. L. Ong, Z. L. Teo, T. F. Tan, et al. A translational perspective towards clinical ai fairness. NPJ Digital Medicine, 6 (1):172, 2023. find
  73. N. F. Liu, K. Lin, J. Hewitt, A. Paranjape, M. Bevilacqua, F. Petroni, and P. Liang. Lost in the middle: How language models use long contexts. Transactions of the Association for Computational Linguistics, 12:157–173, 2024.
  74. R. J. Loos and G. S. Yeo. The genetics of obesity: from discovery to biology. Nature Reviews Genetics, 23(2):120–133, 2022. find
  75. N. López and V. L. Gadsden. Health inequities, social determinants, and intersectionality. In Perspectives on health equity and social determinants of health. National Academies Press (US), 2017. find
  76. M. Y. Lu, B. Chen, D. F. Williamson, R. J. Chen, K. Ikamura, G. Gerber, I. Liang, L. P. Le, T. Ding, A. V. Parwani, et al. A foundational multimodal vision language ai assistant for human pathology. arXiv preprint arXiv:2312.07814, 2023. — [arXiv:2312.07814](https://arxiv.org/abs/2312.07814) find
  77. R. Luo, L. Sun, Y. Xia, T. Qin, S. Zhang, H. Poon, and T.-Y. Liu. BioGPT: generative pre-trained transformer for biomedical text generation and mining. Briefings in bioinformatics, 23(6):bbac409, 2022. find
  78. A. Mandal, S. Leavy, and S. Little. Multimodal composite association score: Measuring gender bias in generative multimodal models. arXiv preprint arXiv:2304.13855, 2023. — [arXiv:2304.13855](https://arxiv.org/abs/2304.13855) find
  79. P. Mascagni, D. Alapatt, A. Garcia, N. Okamoto, A. Vardazaryan, G. Costamagna, B. Dallemagne, and N. Padoy. Surgical data science for safe cholecystectomy: a protocol for segmentation of hepatocystic anatomy and assessment of the critical view of safety. arXiv preprint arXiv:2106.10916, 2021. — [arXiv:2106.10916](https://arxiv.org/abs/2106.10916) find
  80. D. McDuff, M. Schaekermann, T. Tu, A. Palepu, A. Wang, J. Garrison, K. Singhal, Y. Sharma, S. Azizi, K. Kulkarni, et al. Towards accurate differential diagnosis with large language models. arXiv preprint arXiv:2312.00164, 2023. — [arXiv:2312.00164](https://arxiv.org/abs/2312.00164) find
  81. J. Medina-Martínez, C. Saus-Ortega, M. M. Sánchez-Lorente, E. M. Sosa-Palanca, P. García-Martínez, and M. I. Mármol-López. Health inequities in lgbt people and nursing interventions to reduce them: A systematic review. International Journal of Environmental Research and Public Health, 18(22): 11801,… find
  82. Meta. Papers with code - medical, 2024. URL https://paperswithcode.com/area/medical . Accessed: 2024-04-26. ↗
  83. M. Moor, O. Banerjee, Z. S. H. Abad, H. M. Krumholz, J. Leskovec, E. J. Topol, and P. Rajpurkar. Foundation models for generalist medical artificial intelligence. Nature, 616(7956):259–265, 2023a. find
  84. M. Moor, Q. Huang, S. Wu, M. Yasunaga, Y. Dalmia, J. Leskovec, C. Zakka, E. P. Reis, and P. Rajpurkar. Med-flamingo: a multimodal medical few-shot learner. In Machine Learning for Health (ML4H), pages 353–367. PMLR, 2023b.
  85. R. Nakano, J. Hilton, S. Balaji, J. Wu, L. Ouyang, C. Kim, C. Hesse, S. Jain, V. Kosaraju, W. Saunders, et al. WebGPT: Browser-assisted question-answering with human feedback. arXiv preprint arXiv:2112.09332, 2021.
  86. H. Nori, Y. T. Lee, S. Zhang, D. Carignan, R. Edgar, N. Fusi, N. King, J. Larson, Y. Li, W. Liu, et al. Can generalist foundation models outcompete special-purpose tuning? case study in medicine. arXiv preprint arXiv:2311.16452, 2023. find
  87. A. Novin and E. Meyers. Making sense of conflicting science information: Exploring bias in the search engine result page. In Proceedings of the 2017 conference on conference human information interaction and retrieval, pages 175–184, 2017. find
  88. C. I. Nwoye, D. Mutter, J. Marescaux, and N. Padoy. Weakly supervised convolutional lstm approach for tool tracking in laparoscopic videos. International journal of computer assisted radiology and surgery, 14:1059–1067, 2019. find
  89. Z. Obermeyer, B. Powers, C. Vogeli, and S. Mullainathan. Dissecting racial bias in an algorithm used to manage the health of populations. Science, 366(6464):447–453, 2019. find
  90. J. Oh, G. Lee, S. Bae, J.-m. Kwon, and E. Choi. Ecg-qa: A comprehensive question answering dataset combined with electrocardiogram. In A. Oh, T. Neumann, A. Globerson, K. Saenko, M. Hardt, and S. Levine, editors, Advances in Neural Information Processing Systems, volume 36, pages 66277–66288. Curran… find
  91. J. A. Omiye, J. C. Lester, S. Spichak, V. Rotemberg, and R. Daneshjou. Large language models propagate race-based medicine. NPJ Digital Medicine, 6(1):195, 2023. find
  92. L. Ouyang, J. Wu, X. Jiang, D. Almeida, C. Wainwright, P. Mishkin, C. Zhang, S. Agarwal, K. Slama, A. Ray, et al. Training language models to follow instructions with human feedback. Advances in neural information processing systems, 35:27730–27744, 2022.
  93. A. G. Pacheco, G. R. Lima, A. S. Salomao, B. Krohling, I. P. Biral, G. G. de Angelo, F. C. Alves Jr, J. G. Esgario, A. C. Simora, P. B. Castro, et al. PAD-UFES-20: A skin lesion dataset composed of patient data and clinical images collected from smartphones. Data in brief, 32:106221, 2020. find
  94. M. Parmar, A. Naik, H. Gupta, D. Agrawal, and C. Baral. LongBoX: Evaluating transformers on long-sequence clinical tasks, 2023. find
  95. O. Pelka, S. Koitka, J. Rückert, F. Nensa, and C. M. Friedrich. Radiology objects in context (roco): a multimodal image dataset. In Intravascular Imaging and Computer Assisted Stenting and Large-Scale Annotation of Biomedical Data and Expert Label Synthesis: 7th Joint International Workshop, CVII-ST… find
  96. S. R. Pfohl, H. Cole-Lewis, R. Sayres, D. Neal, M. Asiedu, A. Dieng, N. Tomasev, Q. M. Rashid, S. Azizi, N. Rostamzadeh, et al. A toolbox for surfacing health equity harms and biases in large language models. arXiv preprint arXiv:2403.12025, 2024. — [arXiv:2403.12025](https://arxiv.org/abs/2403.12025) find
  97. M. Poli, S. Massaroli, E. Nguyen, D. Y. Fu, T. Dao, S. Baccus, Y. Bengio, S. Ermon, and C. Ré. Hyena hierarchy: Towards larger convolutional language models. In International Conference on Machine Learning, pages 28043–28078. PMLR, 2023. find
  98. S. Qiao, Y. Ou, N. Zhang, X. Chen, Y. Yao, S. Deng, C. Tan, F. Huang, and H. Chen. Reasoning with language model prompting: A survey, 2023.
  99. Y. Qin, S. Liang, Y. Ye, K. Zhu, L. Yan, Y. Lu, Y. Lin, X. Cong, X. Tang, B. Qian, et al. ToolLLM: Facilitating large language models to master 16000+ real-world apis. arXiv preprint arXiv:2307.16789, 2023.
  100. A. Radford, K. Narasimhan, T. Salimans, I. Sutskever, et al. Improving language understanding by generative pre-training. 2018. find
  101. C. Raffel, N. Shazeer, A. Roberts, K. Lee, S. Narang, M. Matena, Y. Zhou, W. Li, and P. J. Liu. Exploring the limits of transfer learning with a unified text-to-text transformer. The Journal of Machine Learning Research, 21(1):5485–5551, 2020.
  102. P. Rajpurkar, E. Chen, O. Banerjee, and E. J. Topol. AI in health and medicine. Nature medicine, 28 (1):31–38, 2022. find
  103. V. Ramesh, N. A. Chi, and P. Rajpurkar. Improving radiology report generation systems by removing hallucinated references to non-existent priors. In A. Parziale, M. Agrawal, S. Joshi, I. Y. Chen, S. Tang, L. Oala, and A. Subbaswamy, editors, Proceedings of the 2nd Machine Learning for Health symposi… find
  104. M. S. Razai, H. K. Kankam, A. Majeed, A. Esmail, and D. R. Williams. Mitigating ethnic disparities in covid-19 and beyond. bmj, 372, 2021. find
  105. M. S. Ríos, M. A. Molina-Rodriguez, D. Londoño, C. A. Guillén, S. Sierra, F. Zapata, and L. F. Giraldo. Cholec80-cvs: An open dataset with an evaluation of strasberg’s critical view of safety for ai. Scientific Data, 10(1):194, 2023. find
  106. D. E. Sanford and S. M. Strasberg. A simple effective method for generation of a permanent record of the critical view of safety during laparoscopic cholecystectomy by intraoperative “doublet” photography. Journal of the American College of Surgeons, 218(2):170–178, 2014. find
  107. L. Sbaffi, J. Walton, J. Blenkinsopp, and G. Walton. Information overload in emergency medicine physicians: a multisite case study exploring the causes, impact, and solutions in four north england national health service trusts. Journal of medical Internet research, 22(7):e19126, 2020. find
  108. T. Schick, J. Dwivedi-Yu, R. Dessì, R. Raileanu, M. Lomeli, E. Hambro, L. Zettlemoyer, N. Cancedda, and T. Scialom. Toolformer: Language models can teach themselves to use tools. Advances in Neural Information Processing Systems, 36, 2024.
  109. N. Shazeer, A. Mirhoseini, K. Maziarz, A. Davis, Q. Le, G. Hinton, and J. Dean. Outrageously large neural networks: The sparsely-gated mixture-of-experts layer. arXiv preprint arXiv:1701.06538, 2017. find
  110. E. Sieferd, N. Mohanty, and R. J. Holden. After visit summary: Not an afterthought. In Proceedings of the International Symposium on Human Factors and Ergonomics in Health Care, volume 8, pages 85–89. SAGE Publications Sage CA: Los Angeles, CA, 2019. find
  111. K. Singhal, S. Azizi, T. Tu, S. S. Mahdavi, J. Wei, H. W. Chung, N. Scales, A. Tanwani, H. Cole-Lewis, S. Pfohl, et al. Large language models encode clinical knowledge. Nature, 620(7972):172–180, 2023a.
  112. K. Singhal, T. Tu, J. Gottweis, R. Sayres, E. Wulczyn, L. Hou, K. Clark, S. Pfohl, H. Cole-Lewis, D. Neal, et al. Towards expert-level medical question answering with large language models. arXiv preprint arXiv:2305.09617, 2023b.
  113. T. Srinivasan and Y. Bisk. Worst of both worlds: Biases compound in pre-trained vision-and-language models. arXiv preprint arXiv:2104.08666, 2021. find
  114. A. Steptoe and P. Zaninotto. Lower socioeconomic status and the acceleration of aging: An outcome-wide analysis. Proceedings of the National Academy of Sciences, 117(26):14911–14917, 2020. find
  115. S. M. Strasberg and M. L. Brunt. Rationale and use of the critical view of safety in laparoscopic cholecystectomy. Journal of the American College of Surgeons, 211(1):132–138, 2010. find
  116. D. Stutz, A. T. Cemgil, A. G. Roy, T. Matejovicova, M. Barsbey, P. Strachan, M. Schaekermann, J. Freyberg, R. Rikhye, B. Freeman, J. P. Matos, U. Telang, D. R. Webster, Y. Liu, G. S. Corrado, Y. Matias, P. Kohli, Y. Liu, A. Doucet, and A. Karthikesalingam. Evaluating AI systems under uncertain groun… find
  117. R. Tanno, D. Barrett, A. Sellergren, S. Ghaisas, S. Dathathri, A. See, J. Welbl, K. Singhal, S. Azizi, T. Tu, et al. Consensus, dissensus and synergy between clinicians and specialist foundation models in radiology report generation. 2024. find
  118. The New England Journal of Medicine. image-challenge , 2024. find
  119. Image challenge. https://www.nejm.org/A. Toma, P. R. Lawler, J. Ba, R. G. Krishnan, B. B. Rubin, and B. Wang. Clinical camel: An open-source expert-level medical language model with dialogue-based knowledge encoding. arXiv preprint arXiv:2305.12031, 2023. ↗
  120. H. Touvron, T. Lavril, G. Izacard, X. Martinet, M.-A. Lachaux, T. Lacroix, B. Rozière, N. Goyal, E. Hambro, F. Azhar, et al. LLaMA: Open and efficient foundation language models. arXiv preprint arXiv:2302.13971, 2023.
  121. T. Tu, S. Azizi, D. Driess, M. Schaekermann, M. Amin, P.-C. Chang, A. Carroll, C. Lau, R. Tanno, I. Ktena, et al. Towards generalist biomedical AI. NEJM AI, 1(3):AIoa2300138, 2024a. find
  122. T. Tu, A. Palepu, M. Schaekermann, K. Saab, J. Freyberg, R. Tanno, A. Wang, B. Li, M. Amin, N. Tomasev, et al. Towards conversational diagnostic AI. arXiv preprint arXiv:2401.05654, 2024b. — [arXiv:2401.05654](https://arxiv.org/abs/2401.05654) find
  123. A. P. Twinanda, S. Shehata, D. Mutter, J. Marescaux, M. De Mathelin, and N. Padoy. Endonet: a deep architecture for recognition tasks on laparoscopic videos. IEEE transactions on medical imaging, 36 (1):86–97, 2016. find
  124. L. K. Umapathi, A. Pal, and M. Sankarasubbu. Med-halt: Medical domain hallucination test for large language models. arXiv preprint arXiv:2307.15343, 2023.
  125. N. Varshney, W. Yao, H. Zhang, J. Chen, and D. Yu. A stitch in time saves nine: Detecting and mitigating hallucinations of llms by validating low-confidence generation. arXiv preprint arXiv:2307.03987, 2023.
  126. A. Vaswani, N. Shazeer, N. Parmar, J. Uszkoreit, L. Jones, A. N. Gomez, Ł. Kaiser, and I. Polosukhin. Attention is all you need. Advances in neural information processing systems, 30, 2017.
  127. P. Wagner, N. Strodthoff, R.-D. Bousseljot, D. Kreiseler, F. I. Lunze, W. Samek, and T. Schaeffter. PTB-XL, a large publicly available electrocardiography dataset. Scientific data, 7(1):1–15, 2020. find
  128. Z. Wan, C. Liu, X. Wang, C. Tao, H. Shen, Z. Peng, J. Fu, R. Arcucci, H. Yao, and M. Zhang. Electrocardiogram instruction tuning for report generation, 2024. find
  129. A. Wang, V. V. Ramaswamy, and O. Russakovsky. Towards intersectionality in machine learning: Including more identities, handling underrepresentation, and performing evaluation. In Proceedings of the 2022 ACM Conference on Fairness, Accountability, and Transparency, pages 336–349, 2022a. find
  130. X. Wang, J. Wei, D. Schuurmans, Q. Le, E. Chi, S. Narang, A. Chowdhery, and D. Zhou. Self-consistency improves chain of thought reasoning in language models. arXiv preprint arXiv:2203.11171, 2022b.
  131. Y. Wang, W. Chen, X. Han, X. Lin, H. Zhao, Y. Liu, B. Zhai, J. Yuan, Q. You, and H. Yang. Exploring the reasoning abilities of multimodal large language models (mllms): A comprehensive survey on emerging trends in multimodal reasoning, 2024. find
  132. A. Ward, J. Li, J. Wang, S. Lakshminarasimhan, A. Carrick, B. Campana, J. Hartford, T. Tiyasirichokchai, S. Virmani, R. Wong, et al. Crowdsourcing dermatology images with google search ads: Creating a real-world skin condition dataset. arXiv preprint arXiv:2402.18545, 2024. — [arXiv:2402.18545](https://arxiv.org/abs/2402.18545) find
  133. L. W. Way, L. Stewart, W. Gantert, K. Liu, C. M. Lee, K. Whang, and J. G. Hunter. Causes and prevention of laparoscopic bile duct injuries: analysis of 252 cases from a human factors and cognitive psychology perspective. Annals of surgery, 237(4):460–469, 2003. find
  134. J. Wei, M. Bosma, V. Y. Zhao, K. Guu, A. W. Yu, B. Lester, N. Du, A. M. Dai, and Q. V. Le. Finetuned language models are zero-shot learners. arXiv preprint arXiv:2109.01652, 2021.
  135. J. Wei, X. Wang, D. Schuurmans, M. Bosma, F. Xia, E. Chi, Q. V. Le, D. Zhou, et al. Chain-of-thought prompting elicits reasoning in large language models. Advances in neural information processing systems, 35:24824–24837, 2022.
  136. Y. Weng and B. Li. Visual answer localization with cross-modal mutual knowledge transfer. In ICASSP 2023-2023 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), pages 1–5. find
  137. D. R. Williams and R. Wyatt. Racial bias in health care and health: challenges and opportunities. Jama, 314(6):555–556, 2015. find
  138. K. Wu, E. Wu, A. Cassasola, A. Zhang, K. Wei, T. Nguyen, S. Riantawan, P. S. Riantawan, D. E. Ho, and J. Zou. How well do llms cite relevant medical references? an evaluation framework and analyses. arXiv preprint arXiv:2402.02008, 2024. — [arXiv:2402.02008](https://arxiv.org/abs/2402.02008) find
  139. S. Xu, L. Yang, C. Kelly, M. Sieniek, T. Kohlberger, M. Ma, W.-H. Weng, A. Kiraly, S. Kazemzadeh, Z. Melamed, et al. ELIXR: Towards a general purpose x-ray artificial intelligence system through alignment of large language models and radiology vision encoders. arXiv preprint arXiv:2308.01317, 2023. — [arXiv:2308.01317](https://arxiv.org/abs/2308.01317) find
  140. F. Yang, M. Cisse, and S. Koyejo. Fairness with overlapping groups; a probabilistic perspective. Advances in neural information processing systems, 33:4067–4078, 2020. find
  141. S. Yao, D. Yu, J. Zhao, I. Shafran, T. L. Griffiths, Y. Cao, and K. Narasimhan. Tree of thoughts: Deliberate problem solving with large language models, 2023. find
  142. J. Yu, Z. Wang, V. Vasudevan, L. Yeung, M. Seyedhosseini, and Y. Wu. Coca: Contrastive captioners are image-text foundation models. arXiv preprint arXiv:2205.01917, 2022.
  143. X. Yue, Y. Ni, K. Zhang, T. Zheng, R. Liu, G. Zhang, S. Stevens, D. Jiang, W. Ren, Y. Sun, et al. MMMU: A massive multi-discipline multimodal understanding and reasoning benchmark for expert agi. arXiv preprint arXiv:2311.16502, 2023.
  144. C. Zakka, R. Shad, A. Chaurasia, A. R. Dalal, J. L. Kim, M. Moor, R. Fong, C. Phillips, K. Alexander, E. Ashley, et al. Almanac—retrieval-augmented language models for clinical medicine. NEJM AI, 1 (2):AIoa2300068, 2024. find
  145. J. M. Zambrano Chaves, S.-C. Huang, Y. Xu, H. Xu, N. Usuyama, S. Zhang, F. Wang, Y. Xie, M. Khademi, Z. Yang, et al. Training small multimodal models to bridge biomedical competency gap: A case study in radiology imaging. arXiv preprint arXiv:2403.08002, 2024. find
  146. E. Zelikman, J. Mu, N. D. Goodman, and Y. T. Wu. Star: Self-taught reasoner bootstrapping reasoning with reasoning. Advances in Neural Information Processing Systems (NeurIPS), 2022. find
  147. T. Zhang, S. G. Patil, N. Jain, S. Shen, M. Zaharia, I. Stoica, and J. E. Gonzalez. Raft: Adapting language model to domain specific rag. arXiv preprint arXiv:2403.10131, 2024.
  148. D. Zhou, N. Schärli, L. Hou, J. Wei, N. Scales, X. Wang, D. Schuurmans, C. Cui, O. Bousquet, Q. Le, and E. Chi. Least-to-most prompting enables complex reasoning in large language models, 2023.

Updated

↑ back to top

This page in Markdown → https://md.research.elamur.ai/free/en/papers/saab-2024-capabilities-gemini-models-medicine/