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Nature 2021: all accepted papers

3,641 papers · page 1 of 37 · the most cited first · ← Nature 2021

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  1. Highly accurate protein structure prediction with AlphaFoldJohn Jumper, Richard Evans, Alexander Pritzel et al.43,269 citations · our summary
  2. Towards complete and error-free genome assemblies of all vertebrate species ↗Arang Rhie, Shane McCarthy, Olivier D. Fedrigo et al.3,098 citations
  3. Pseudo-halide anion engineering for α-FAPbI3 perovskite solar cells ↗Jaeki Jeong, Minjin Kim, Jongdeuk Seo et al.3,072 citations
  4. Highly accurate protein structure prediction for the human proteome ↗Kathryn Tunyasuvunakool, Jonas Adler, Zachary Wu et al.2,998 citations
  5. Efficient perovskite solar cells via improved carrier management ↗Jason J. Yoo, Gabkyung Seo, Matthew R. Chua et al.2,931 citations
  6. Designing the next generation of proton-exchange membrane fuel cells ↗Kui Jiao, Jin Xuan, Qing Du et al.2,915 citations
  7. Detection of a SARS-CoV-2 variant of concern in South Africa ↗Houriiyah Tegally, Eduan Wilkinson, Marta Giovanetti et al.2,509 citations
  8. Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7 ↗Pengfei Wang, Manoj S. Nair, Lihong Liu et al.2,310 citations
  9. A 20-year retrospective review of global aquaculture ↗Rosamond L. Naylor, Ronald W. Hardy, Alejandro H. Buschmann et al.2,233 citations
  10. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program ↗Daniel Taliun, Daniel Harris, Michael D. Kessler et al.2,192 citations
  11. Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies ↗Yunlong Cao, Jing Wang, Fanchong Jian et al.1,996 citations
  12. Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization ↗Delphine Planas, David L. Veyer, Artem Baidaliuk et al.1,987 citations
  13. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer ↗Chao Mao, Xiaoguang Liu, Yilei Zhang et al.1,900 citations
  14. Accelerated global glacier mass loss in the early twenty-first century ↗Romain Hugonnet, Robert McNabb, Étienne Berthier et al.1,889 citations
  15. Parallel convolutional processing using an integrated photonic tensor core ↗J. Feldmann, N. Youngblood, M. Karpov et al.1,874 citations
  16. Photocatalytic solar hydrogen production from water on a 100-m2 scale ↗Hiroshi Nishiyama, Taro Yamada, Mamiko Nakabayashi et al.1,776 citations
  17. In situ Raman spectroscopy reveals the structure and dissociation of interfacial water ↗Yao-Hui Wang, Shisheng Zheng, Weimin Yang et al.1,703 citations
  18. Exploring tissue architecture using spatial transcriptomics ↗Anjali N. Rao, Dalia Barkley, Gustavo S. França et al.1,669 citations
  19. Evolution of antibody immunity to SARS-CoV-2 ↗Christian Gaebler, Zijun Wang, Julio C. C. Lorenzi et al.1,665 citations
  20. Developing fibrillated cellulose as a sustainable technological material ↗Tian Li, Chaoji Chen, Alexandra H. Brozena et al.1,663 citations
  21. Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England ↗Erik Volz, Swapnil Mishra, Meera A Chand et al.1,601 citations
  22. Strong tough hydrogels via the synergy of freeze-casting and salting out ↗Mutian Hua, Shuwang Wu, Yanfei Ma et al.1,519 citations
  23. 11 TOPS photonic convolutional accelerator for optical neural networks ↗Xingyuan Xu, Mengxi Tan, Bill Corcoran et al.1,518 citations
  24. Considerable escape of SARS-CoV-2 Omicron to antibody neutralization ↗Delphine Planas, Nell Saunders, Piet Maes et al.1,511 citations
  25. High-dimensional characterization of post-acute sequelae of COVID-19 ↗Ziyad Al‐Aly, Yan Xie, Benjamin C. Bowe1,511 citations
  26. Satellite imaging reveals increased proportion of population exposed to floods ↗Beth Tellman, Jonathan A. Sullivan, C Kuhn et al.1,463 citations
  27. Ultralow contact resistance between semimetal and monolayer semiconductors ↗Pin‐Chun Shen, Cong Su, Yuxuan Cosmi Lin et al.1,402 citations
  28. High and rising economic costs of biological invasions worldwide ↗Christophe Amidi Diagne, Boris Leroy, Anne‐Charlotte Vaissière et al.1,398 citations
  29. Promises and prospects of two-dimensional transistors ↗Yuan Liu, Xidong Duan, Xidong Duan et al.1,356 citations
  30. Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia ↗Eliza Yankova, Wesley Blackaby, Mark Robert Albertella et al.1,352 citations
  31. mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants ↗Zijun Wang, Fabian Schmidt, Yiska Weisblum et al.1,341 citations
  32. Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization ↗Sandile Cele, Laurelle Jackson, David S. Khoury et al.1,331 citations
  33. SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion ↗Petra Mlčochová, Steven A. Kemp, Mahesh Shanker Dhar et al.1,330 citations
  34. Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2 ↗Lihong Liu, Sho Iketani, Yicheng Guo et al.1,286 citations
  35. NASH limits anti-tumour surveillance in immunotherapy-treated HCC ↗Dominik Reinhard Pfister, Nicolás Gonzalo Núñez, Roser Pinyol et al.1,280 citations
  36. Metabolic support of tumour-infiltrating regulatory T cells by lactic acid ↗McLane J. Watson, Paolo Vignali, Steven J. Mullett et al.1,259 citations
  37. Pattern-recognition receptors are required for NLR-mediated plant immunity ↗Minhang Yuan, Zeyu Jiang, Guozhi Bi et al.1,257 citations
  38. Self-powered soft robot in the Mariana Trench ↗Guorui Li, Xiangping Chen, Fanghao Zhou et al.1,198 citations
  39. Shifting attention to accuracy can reduce misinformation online ↗Gordon Pennycook, Ziv G. Epstein, Mohsen Mosleh et al.1,139 citations
  40. Mutual potentiation of plant immunity by cell-surface and intracellular receptors ↗Bruno Pok Man Ngou, Hee-Kyung Ahn, Pingtao Ding et al.1,100 citations
  41. SARS-CoV-2 evolution during treatment of chronic infection ↗Steven A. Kemp, Dami A. Collier, Rawlings P. Datir et al.1,095 citations
  42. Cross-tissue organization of the fibroblast lineage ↗Matthew B. Buechler, Rachana Pradhan, Akshay T. Krishnamurty et al.1,087 citations
  43. Large-area display textiles integrated with functional systems ↗Xiang Shi, Yong Zuo, Peng Zhai et al.1,085 citations
  44. Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift ↗Elisabetta Cameroni, John E. Bowen, Laura E. Rosen et al.1,080 citations
  45. Amazonia as a carbon source linked to deforestation and climate change ↗Luciana V. Gatti, Luana S. Basso, John Bharat Miller et al.1,072 citations
  46. Bayesian reaction optimization as a tool for chemical synthesis ↗Benjamin J. Shields, Jason M. Stevens, Jun Li et al.1,044 citations
  47. An integrated space-to-ground quantum communication network over 4,600 kilometres ↗Yu-Ao Chen, Qiang Zhang, Teng‐Yun Chen et al.1,040 citations
  48. Cell-programmed nutrient partitioning in the tumour microenvironment ↗Bradley I. Reinfeld, Matthew Z. Madden, Melissa M. Wolf et al.1,023 citations
  49. Skilful precipitation nowcasting using deep generative models of radar ↗Suman V. Ravuri, Karel Lenc, Matthew Willson et al.1,006 citations
  50. Diverse functional autoantibodies in patients with COVID-19 ↗Eric Y. Wang, Tianyang Mao, Jon Klein et al.992 citations
  51. Quantum phases of matter on a 256-atom programmable quantum simulator ↗Sepehr Ebadi, Tout T. Wang, Harry Levine et al.987 citations
  52. Mapping the human genetic architecture of COVID-19 ↗COVID-19 Host Genetics Initiative, COVID-19 Host Genetics InitiativeLeadership, Mari Niemi et al.983 citations
  53. Exome sequencing and analysis of 454,787 UK Biobank participants ↗Joshua Backman, Alexander H. Li, Anthony Marcketta et al.976 citations
  54. The power of genetic diversity in genome-wide association studies of lipids ↗Sarah E. Graham, Shoa L. Clarke, Kuan-Han Wu et al.967 citations
  55. High-performance brain-to-text communication via handwriting ↗Francis R. Willett, Donald T. Avansino, Leigh R. Hochberg et al.961 citations
  56. An aged immune system drives senescence and ageing of solid organs ↗Matthew J. Yousefzadeh, Rafael R. Flores, Yi Zhun Zhu et al.957 citations
  57. Unextractable fossil fuels in a 1.5 °C world ↗Dan Welsby, James Price, Steve Pye et al.926 citations
  58. Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7 ↗CMMID COVID-19 Working Group, Nicholas G. Davies, Christopher I Jarvis et al.922 citations
  59. BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans ↗Uğur Şahin, Alexander Muik, Isabel Vogler et al.913 citations
  60. The central role of DNA damage in the ageing process ↗Björn Schumacher, Joris Pothof, Jan Vijg et al.898 citations
  61. Swarm Learning for decentralized and confidential clinical machine learning ↗Stefanie Warnat‐Herresthal, Hartmut Schultze, Krishnaprasad Shastry et al.879 citations
  62. Structure-based classification of tauopathies ↗Yang Shi, Wenjuan Zhang, Yang Yang et al.873 citations
  63. Tunable strongly coupled superconductivity in magic-angle twisted trilayer graphene ↗Jeong Min Park, Yuan Cao, Kenji Watanabe et al.855 citations
  64. High-resolution X-ray luminescence extension imaging ↗Xiangyu Ou, Xian Qin, Bolong Huang et al.853 citations
  65. NINJ1 mediates plasma membrane rupture during lytic cell death ↗Nobuhiko Kayagaki, Opher S. Kornfeld, Bettina L. Lee et al.838 citations
  66. Leading hadronic contribution to the muon magnetic moment from lattice QCD ↗Sz. Borsányi, Z. Fodor, Jana N. Guenther et al.824 citations
  67. Ligand-engineered bandgap stability in mixed-halide perovskite LEDs ↗Yasser Hassan, Jong Hyun Park, Michael L. Crawford et al.824 citations
  68. SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses ↗Jackson S. Turner, Jane A. O’Halloran, Elizaveta Kalaidina et al.824 citations
  69. A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis ↗Shenbin Liu, Zhifu Wang, Yang‐Shuai Su et al.823 citations
  70. Direct observation of chemical short-range order in a medium-entropy alloy ↗Xuefei Chen, Qi S. Wang, Zhiying Cheng et al.819 citations
  71. Protecting the global ocean for biodiversity, food and climate ↗Enric Sala, Juan Mayorga, Darcy Bradley et al.811 citations
  72. Half a century of global decline in oceanic sharks and rays ↗Nathan Pacoureau, Cassandra L. Rigby, Peter M. Kyne et al.808 citations
  73. Comparative cellular analysis of motor cortex in human, marmoset and mouse ↗Trygve E. Bakken, Nikolas L. Jorstad, Qiwen Hu et al.805 citations
  74. COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets ↗Toni Marie Delorey, Carly G.K. Ziegler, Graham Heimberg et al.794 citations
  75. Distinct fission signatures predict mitochondrial degradation or biogenesis ↗Tatjana Kleele, Timo Rey, Julius Winter et al.787 citations
  76. In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates ↗Kiran Musunuru, Alexandra C. Chadwick, Taiji Mizoguchi et al.785 citations
  77. AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence ↗SangJoon Lee, Rajendra Karki, Yaqiu Wang et al.783 citations
  78. Disease variant prediction with deep generative models of evolutionary data ↗Jonathan Frazer, Pascal Notin, Mafalda Dias et al.782 citations
  79. Closed-loop recycling of polyethylene-like materials ↗Manuel Häußler, Marcel Eck, Dario Rothauer et al.752 citations
  80. Distribution control enables efficient reduced-dimensional perovskite LEDs ↗Dongxin Ma, Kebin Lin, Yitong Dong et al.752 citations
  81. A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis ↗Martina Absinta, Dragan Maric, Marjan Gharagozloo et al.751 citations
  82. Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2 ↗Dami A. Collier, Isabella A.T.M. Ferreira, Prasanti Kotagiri et al.747 citations
  83. MicroRNA sequence codes for small extracellular vesicle release and cellular retention ↗Rubén García-Martín, Guoxiao Wang, Bruna Brasil Brandão et al.731 citations
  84. Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia ↗Rogan A. Grant, Luisa Morales‐Nebreda, Nikolay S. Markov et al.727 citations
  85. Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection ↗Zijun Wang, Frauke Muecksch, Dennis J. Schaefer-Babajew et al.721 citations
  86. The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer ↗Yelena Yuriy Janjigian, Akihito Kawazoe, Patricio Eduardo Yanez et al.720 citations
  87. Cells of the human intestinal tract mapped across space and time ↗Rasa Elmentaite, Natsuhiko Kumasaka, Kenny Roberts et al.699 citations
  88. Correlative operando microscopy of oxygen evolution electrocatalysts ↗J. Tyler Mefford, Andrew R. Akbashev, Minkyung Kang et al.699 citations
  89. Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis ↗Bryan A. Johnson, Xuping Xie, Adam L. Bailey et al.693 citations
  90. BNT162b vaccines protect rhesus macaques from SARS-CoV-2 ↗Annette B. Vogel, Isis Kanevsky, Ye Che et al.691 citations
  91. Thermal-expansion offset for high-performance fuel cell cathodes ↗Yuan Zhang, Bin Chen, Daqin Guan et al.691 citations
  92. Widespread deoxygenation of temperate lakes ↗Stephen F. Jane, Gretchen J. A. Hansen, Benjamin Michael Kraemer et al.690 citations
  93. A trade-off between plant and soil carbon storage under elevated CO2 ↗César Terrer, Richard P. Phillips, Bruce A. Hungate et al.687 citations
  94. Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV ↗Alexey Stukalov, Virginie Girault, Vincent Grass et al.685 citations
  95. Quantum simulation of 2D antiferromagnets with hundreds of Rydberg atoms ↗Pascal Scholl, Michael Schuler, Hannah J. Williams et al.685 citations
  96. A molecular single-cell lung atlas of lethal COVID-19 ↗Johannes C. Melms, Jana Biermann, Huachao Huang et al.679 citations

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