A Self-Evolving LLM Agent Framework for Role-Based Norm Compliance in Healthcare
Paper · 2026 · Haijie Ruan, Xiaowu Jiang, Zhanpeng LI et al.
Summary
The paper addresses a weakness of LLM agents in clinical role-play. Roles are usually fixed prompts and safety relies on one-off filters, so problems that build up over many turns slip through. Examples include missed escalation, a trainee overstepping scope, and gradual style drift. The authors propose a self-evolving agent whose identity has three parts: a role, a vector of communicator traits seeded from survey-based priors, and a context-dependent style. Role duties are encoded as hard IF–THEN norms with severity levels 1–5, while traits act only as soft preferences. The agent logs norm-annotated trajectories in structured memory. It then reflects on two time scales: quick diagnosis of responsibility errors, and longer-term checks for identity drift. Finally, it rewrites its prompts and identity parameters through preference-style optimization using AI feedback. Tests in a simulated multi-role hospital setting covered medication review, emergency triage and discharge planning. The full agent lowered severity-weighted norm risk and generally improved coordination and trust-like scores over static baselines. This points toward safer long-horizon behaviour for agents in high-stakes settings.
Key points
- The environment is a partially observable multi-role setting with DOCTOR, NURSE, ADMIN and TRAINEE roles. Candidate replies are ranked by a weighted mix of a norm-violation penalty and trait alignment, so hard norms always override style.
- The full agent was compared with three baselines: Plain LLM, Norm-Instructed and Reflection-only. Aggregated ablation deltas in severity-weighted norm risk (SNR) were −2.83, −2.39 and −1.31 respectively. Gains in the trust-like signal (TSS) were +1.53, +1.20 and +0.55.
- On a 1–10 scale, the full agent's coordination score (CBS) on the second task was 7.22, against 5.22 for Plain LLM. However, its TSS on the first task (6.78) was slightly below Reflection-only (6.89).
- Embedding-based identity consistency (ICS) gave mixed results. The authors argue that stricter norm enforcement changes surface wording even when role adherence (RAR) improves.
- The work uses only simulation and no real patient data. Many metrics rely on rubric-guided LLM judges, and the norm set and severity weights are modelling choices rather than clinically complete rules.
Institutions
Fields, topics and concepts
📚 Shelves 8The field of science this work belongs to (OpenAlex fields).Computer Science · 16,667 worksArtificial Intelligence · 16,194 worksArts and Humanities · 16,039 worksLanguage and Linguistics · 15,891 worksSocial Sciences · 1,772 worksSafety Research · 543 worksMedicine · 241 worksHealth Informatics · 184 works
Cite
Cite as Haijie Ruan, Xiaowu Jiang, Zhanpeng LI, Wei Jia, Xuanwu Xu, Xiao-Fen Shan, Shujie Chen and Xindong Ye. 2026. A Self-Evolving LLM Agent Framework for Role-Based Norm Compliance in Healthcare. Findings of the Association for Computational Linguistics: ACL 2026.
@inproceedings{ruan2026self,
title = {{A Self-Evolving LLM Agent Framework for Role-Based Norm Compliance in Healthcare}},
author = {Haijie Ruan, Xiaowu Jiang, Zhanpeng LI, Wei Jia, Xuanwu Xu, Xiao-Fen Shan, Shujie Chen and Xindong Ye},
booktitle = {Findings of the Association for Computational Linguistics: ACL 2026},
year = {2026},
doi = {10.18653/v1/2026.findings-acl.1133},
url = {https://doi.org/10.18653/v1/2026.findings-acl.1133}
}References
- Julie Apker, Larry A Mallak, E Brooks Applegate III, Scott C Gibson, Jason J Ham, Neil A Johnson, and Richard L Street Jr. 2010. Exploring emergency physician–hospitalist handoff interactions: development of the handoff communication assessment. Annals of emergency medicine, 55(2):161–170. in llm-ag… find
- Xuehai He, Shu Chen, Zeqian Ju, Xiangyu Dong, Hongchao Fang, Sicheng Wang, Yue Yang, Jiaqi Zeng, Ruisi Zhang, Ruoyu Zhang, and 1 others. 2020. Meddialog: Two large-scale medical dialogue datasets. arXiv preprint arXiv:2004.03329. — [arXiv:2004.03329](https://arxiv.org/abs/2004.03329) find
- Shalini Chandra, Anuragini Shirish, and Shirish C Srivastava. 2022. To be or not to be. . . human? theorizing the role of human-like competencies in conversational artificial intelligence agents. Journal of Management Information Systems, 39(4):969–1005. find
- Holly Janes, Margaret S Pepe, and Wen Gu. 2008. Assessing the value of risk predictions by using risk stratification tables. Annals of internal medicine, 149(10):751–760. find
- Shreyas Chaudhari, Pranjal Aggarwal, Vishvak Murahari, Tanmay Rajpurohit, Ashwin Kalyan, Karthik Narasimhan, Ameet Deshpande, and Bruno Castro da Silva. 2025. Rlhf deciphered: A critical analysis of reinforcement learning from human feedback for llms. ACM Computing Surveys, 58(2):1–37. find
- Erika Janssen, Rebecca McLagan, Jessica Habeck, Seon Yoon Chung, Erin C McArthur, and Polly Anderson. 2025. Barriers to breakthroughs: A scoping review of generative ai in healthcare simulation. Clinical Simulation in Nursing, 107:101791. find
- Hongzhan Chen, Hehong Chen, Ming Yan, Wenshen Xu, Gao Xing, Weizhou Shen, Xiaojun Quan, Chenliang Li, Ji Zhang, and Fei Huang. 2024. Socialbench: Sociality evaluation of role-playing conversational agents. In Findings of the Association for Computational Linguistics: ACL 2024, pages 2108– 2126. find
- Xiaolan Chen, Jiayang Xiang, Shanfu Lu, Yexin Liu, Mingguang He, and Danli Shi. 2025. Evaluating large language models and agents in healthcare: key challenges in clinical applications. Intelligent Medicine. find
- Alexander M Clark, Tiny Jaarsma, Patricia Strachan, Patricia M Davidson, Megan Jerke, James M Beattie, Amanda S Duncan, Chantal F Ski, and David R Thompson. 2011. Effective communication and ethical consent in decisions related to icds. Nature Reviews Cardiology, 8(12):694–705. find
- Chrisantha Fernando, Dylan Banarse, Henryk Michalewski, Simon Osindero, and Tim Rocktäschel. 2023. Promptbreeder: Self-referential self-improvement via prompt evolution. arXiv preprint arXiv:2309.16797.
- Yubin Ge, Salvatore Romeo, Jason Cai, Monica Sunkara, and Yi Zhang. 2025. Samule: Self-learning agents enhanced by multi-level reflection. In Proceedings of the 2025 Conference on Empirical Methods in Natural Language Processing, pages 16602– 16621. find
- Dylan Hadfield-Menell, McKane Andrus, and Gillian Hadfield. 2019. Legible normativity for ai alignment: The value of silly rules. In Proceedings of the 2019 AAAI/ACM Conference on AI, Ethics, and Society, pages 115–121. find
- Kostas Hatalis, Despina Christou, Joshua Myers, Steven Jones, Keith Lambert, Adam Amos-Binks, Zohreh Dannenhauer, and Dustin Dannenhauer. 2023. Memory matters: The need to improve long-term memory Jiaming Ji, Tianyi Qiu, Boyuan Chen, Jiayi Zhou, Borong Zhang, Donghai Hong, Hantao Lou, Kaile Wang, Ya… find
- Ruili Jiang, Kehai Chen, Xuefeng Bai, Zhixuan He, Juntao Li, Muyun Yang, Tiejun Zhao, Liqiang Nie, and Min Zhang. 2024. A survey on human preference learning for large language models. arXiv preprint arXiv:2406.11191. — [arXiv:2406.11191](https://arxiv.org/abs/2406.11191) find
- Philippe Laban, Hiroaki Hayashi, Yingbo Zhou, and Jennifer Neville. 2025. Llms get lost in multi-turn conversation. arXiv preprint arXiv:2505.06120.
- Maik Larooij and Petter Törnberg. 2025. Validation is the central challenge for generative social simulation: a critical review of llms in agent-based modeling. Artificial Intelligence Review, 59(1):15. find
- France Légaré, Rhéda Adekpedjou, Dawn Stacey, Stéphane Turcotte, Jennifer Kryworuchko, Ian D Graham, Anne Lyddiatt, Mary C Politi, Richard Thomson, Glyn Elwyn, and 1 others. 2018. Interventions for increasing the use of shared decision making by healthcare professionals. Cochrane database of systema… find
- Jiaqi Li, Xinyi Dong, Yang Liu, Zhizhuo Yang, Quansen Wang, Xiaobo Wang, Song-Chun Zhu, Zixia Jia, and Zilong Zheng. 2025. Reflectevo: Improving meta introspection of small llms by learning self-reflection. In Findings of the Association for Computational Linguistics: ACL 2025, pages 16948–16966. find
- Ernest Lim, Yajie Vera He, Jared Joselowitz, Kate Preston, Mohita Chowdhury, Louis Williams, Aisling Higham, Katrina Mason, Mariane Melo, Tom Lawton, and 1 others. 2025. Matrix: Multi-agent simulation framework for safe interactions and contextual clinical conversational evaluation. arXiv preprint a… — [arXiv:2508.19163](https://arxiv.org/abs/2508.19163) find
- Nikita Mehandru, Brenda Y Miao, Eduardo Rodriguez Almaraz, Madhumita Sushil, Atul J Butte, and Ahmed Alaa. 2024. Evaluating large language models as agents in the clinic. NPJ digital medicine, 7(1):84. find
- Shunyu Yao, Jeffrey Zhao, Dian Yu, Nan Du, Izhak Shafran, Karthik R Narasimhan, and Yuan Cao. 2022. React: Synergizing reasoning and acting in language models. In The eleventh international conference on learning representations.
- Erika Mori, Yue Qiu, Hirokatsu Kataoka, and Yoshimitsu Aoki. 2025. A comprehensive analysis of a social intelligence dataset and response tendencies between large language models (llms) and humans. Sensors, 25(2):477. find
- Zihao Yi, Jiarui Ouyang, Zhe Xu, Yuwen Liu, Tianhao Liao, Haohao Luo, and Ying Shen. 2024. A survey on recent advances in llm-based multi-turn dialogue systems. ACM Computing Surveys.
- Joon Sung Park, Joseph O’Brien, Carrie Jun Cai, Meredith Ringel Morris, Percy Liang, and Michael S Bernstein. 2023. Generative agents: Interactive simulacra of human behavior. In Proceedings of the 36th annual acm symposium on user interface software and technology, pages 1–22. find
- Marijana Peti, Frano Petric, and Stjepan Bogdan. 2023. Decentralized coordination of multi-agent systems based on pomdps and consensus for active perception. IEEE access, 11:52480–52491. find
- Kambiz Saffarizadeh, Mark Keil, Maheshwar Boodraj, and Tawfiq Alashoor. 2024. “my name is alexa. what’s your name?” the impact of reciprocal self-disclosure on post-interaction trust in conversational agents. Journal of the Association for Information Systems, 25(3):528–568. find
- Jessica Schluter, Philippa Seaton, and Wendy Chaboyer. 2011. Understanding nursing scope of practice: A qualitative study. International journal of nursing studies, 48(10):1211–1222. find
- Tejasvee Sheokand, Garveet Jain, Arshdeep Bahga, and Vijay K Madisetti. 2025. Enhancing llm reasoning capabilities through brokered multi-expert reflection. IEEE Access. find
- Sri Yash Tadimalla and Mary Lou Maher. 2024. Implications of identity in ai: Creators, creations, and consequences. In Proceedings of the AAAI Symposium Series, volume 3, pages 528–535. find
- Lisa Thiele, Arthas Flabouris, and Campbell Thompson. 2020. Acute clinical deterioration and consumer escalation in the hospital setting: a literature review. Resuscitation, 156:72–83. find
- Charles Vincent, Sally Taylor-Adams, and Nicola Stan-hope. 1998. Framework for analysing risk and safety in clinical medicine. Bmj, 316(7138):1154–1157. find
- Noah Wang, Zy Peng, Haoran Que, Jiaheng Liu, Wangchunshu Zhou, Yuhan Wu, Hongcheng Guo, Ruitong Gan, Zehao Ni, Jian Yang, and 1 others. 2024. Rolellm: Benchmarking, eliciting, and enhancing role-playing abilities of large language models. In Findings of the Association for Computational Linguistics:…
- Wujiang Xu, Zujie Liang, Kai Mei, Hang Gao, Juntao Tan, and Yongfeng Zhang. 2025. A-mem: Agentic memory for llm agents. arXiv preprint arXiv:2502.12110.
- Huizi Yu, Jiayan Zhou, Lingyao Li, Shan Chen, Jack Gallifant, Anye Shi, Jie Sun, Xiang Li, Jingxian He, Wenyue Hua, and 1 others. 2025. Simulated patient systems powered by large language model-based ai agents offer potential for transforming medical education. Communications Medicine. find
- Tatiana Zenzano, Janet D Allan, Mary Beth Bigley, Reamer L Bushardt, David R Garr, Ken Johnson, William Lang, Rika Maeshiro, Susan M Meyer, Stephen C Shannon, and 1 others. 2011. The roles of healthcare professionals in implementing clinical prevention and population health. American journal of prev… find
- Zeyu Zhang, Quanyu Dai, Xiaohe Bo, Chen Ma, Rui Li, Xu Chen, Jieming Zhu, Zhenhua Dong, and Ji-Rong Wen. 2025. A survey on the memory mechanism of large language model-based agents. ACM Transactions on Information Systems, 43(6):1–47. find
- Lianmin Zheng, Wei-Lin Chiang, Ying Sheng, Siyuan Zhuang, Zhanghao Wu, Yonghao Zhuang, Zi Lin, Zhuohan Li, Dacheng Li, Eric Xing, and 1 others. 2023. Judging llm-as-a-judge with mt-bench and chatbot arena. Advances in neural information processing systems, 36:46595–46623.
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